Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study

Table 2 Comparison of pain as determined by visual analogue scale in patients with knee osteoarthritis

Visit	Curcumin (N = 70)	Diclofenac (N = 69)	P value
Baseline	7.84 ± 0.63	7.81 ± 0.73	0.79^t
Day 14	4.69 ± 0.79	4.58 ± 0.60	0.38^t
Day 28	2.20 ± 0.81	2.20 ± 0.61	0.98^t
Change at day 14	−3.16 ± 0.79	−3.23 ± 0.91	0.61^t
Change at day 28	−5.93 ± 0.99	−5.61 ± 0.88	0.82^t
P value	P <0.01^wc	P <0.01^wc
VAS reduction % ≤ 50	N = 4	N = 2	P = 0.68^f
VAS reduction % > 50	N = 66	N = 67	P = 0.68^f

Values are expressed in mean ± standard deviation
Abbreviations: f Fisher exact test, N number of patients in each group, t independent t test, wc Wilcoxon signed-rank test
P <0.05 is considered a statistically significant difference. Visual analogue scale (VAS) is from 0 to 10, where 0 indicates “No pain” and 10 indicates “Worst possible pain”. Change in mean score at days 14 and 28 is calculated from baseline VAS score

ISSN: 1745-6215