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Table 2 Long-term outcomes assessments*

From: The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial

  Domain Test name
Cognition Attention Attention (WAIS-IV Digit Span) [77] and delirium (Telephone Confusion Assessment Method) [78]
Executive function Executive functioning (Hayling Test) [79]
Language Language (Controlled Oral Word Association Test or COWA) [80]
Memory Memory (Paragraph Recall from the WMS-IV) [82]
Orientation Orientation (Telephone Interview for Cognitive Status) [81]
Reasoning Reasoning (WAIS-IV Similarities) [77]
Functioning Basic and high-order functioning Activities of daily living (Katz ADL) [83]
Employment (Employment Questionnaire) and instrumental activities of daily living (Functional Activities Questionnaire) [84]
Mental health Depression
Depression (Beck Depression Inventory-II) [85] and PTSD (Post-Traumatic Stress Disorder Checklist for the DSM-V)
Quality of life General quality of life EuroQol, 5 dimension (EQ5D) [87]
  1. Abbreviations: DSM-V Diagnostic and Statistical Manual of Mental Disorders Version 5, EQ5D European Quality of Life Scale Five Dimensions, EuroQol European Quality of Life Scale, WAIS-IV Wechsler Adult Intelligence Scale Version 4, WMS-IV Wechsler Memory Scale Version 4
  2. *All long-term outcomes will be conducted using valid and sensitive telephone-based neurocognitive assessments [65]