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Table 2 Inter-observer reliability of different types of stroke classification systems

From: Stroke aetiological classification reliability and effect on trial sample size: systematic review, meta-analysis and statistical modelling

Study

Classification system

κ

95% CI

TOAST classification system

 Ay et al., 2005 [17] (n = 50)

TOAST

0.78

0.64–0.92

 Fure et al., 2005 [16] (n = 38)

TOAST

0.30

*

 Goldstein et al., 2001a [19] (n = 14)

TOAST (11 categories)

0.29

0.21–0.37

TOAST

0.42

0.32–0.53

 Goldstein et al., 2001b [19] (n = 20)

TOAST computerised algorithm

0.68

0.44–0.91

 Gordon et al., 1993 [22] (n = 18)

TOAST

0.64

*

 Han et al., 2007 [15] (n = 200)

TOAST

0.78

*

 Meschia et al., 2006 [20] (n = 30)

TOAST

0.54

0.48–0.60

 Nam et al., 2012 [21] (n = 70)

iTOAST

0.79

0.71–0.87

TOAST

0.69

0.60–0.78

 Selvarajah et al., 2009 [18] (n = 90)

TOAST

0.42

0.32–0.52**

 Wolf et al., 2012 [23] (n = 103)

TOAST

0.95

*

CCS

 Arsava et al., 2010 [27] (n = 50)

CCS: 5 subtype

0.80

0.78–0.81

8 subtype

0.79

0.77–0.80

16 subtype

0.70

0.69–0.71

 Ay et al., 2005 [17] (n = 50)

5 subtype

0.86

0.76–0.96

 Ay et al., 2007 [28] (n = 50)

5 subtype

0.86

0.81–0.91

8 subtype

0.85

0.80–0.89

16 subtype

0.80

0.76–0.83

 Marnane et al., 2010 [26] (n = 381)

5 subtype

0.64

0.44–0.82**

ASCO classification system

 Chen et al., 2013 [25] (n = 419)

Phenotype: A

0.79

0.74–0.83

S

0.80

0.75–0.85

C

0.87

0.83–0.91

O

0.86

0.78–0.94

 Marnane et al., 2010 [26] (n = 381)

A

0.79

*

S

0.48

*

C

0.88

*

O

0.66

*

 Wolf et al., 2012 [23] (n = 103)

A

0.95

*

S

0.95

*

C

1.00

*

O

0.92

*

Other classification system

 Han et al., 2007 [15] (n = 200)

Han et al. (2007) classification

0.82

*

  1. CI confidence interval, TOAST Trial of Org 10172 in Acute Stroke Treatment, CCS Causative Classification of Stroke System, ASCO atherosclerosis, small vessel disease, cardiac source
  2. *Unknown 95% CI
  3. **Estimates provided by author