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Table 6 Estimated glycated haemoglobin (HbA1c) and between-group differences by history of severe hypoglycaemia and personalised HbA1c target for intervention and control groups (sub-group analyses)

From: Update on the General Practice Optimising Structured Monitoring to Improve Clinical Outcomes in Type 2 Diabetes (GP-OSMOTIC) trial: statistical analysis plan for a multi-centre randomised controlled trial

  Estimated mean HbA1c (95% CI) Difference in estimated mean HbA1c and HbA1c target Unadjusted Adjusteda
Intervention group (n=) Control group (n=) Intervention group (n=) Control group (n=) Intervention vs. control between-group differences (95% CI) P value Intervention vs. control between-group differences (95% CI) P value
Severe hypoglycaemia
History of severe hypoglycaemiab
 Baseline           
 6 months           
 12 months           
No history of severe hypoglycaemiac           
 Baseline           
 6 months           
 12 months           
Personalised HbA1c target
Personalised targetd
 Baseline           
 6 months           
 12 months           
No personalised targete
 Baseline           
 6 months           
 12 months           
  1. CI confidence interval
  2. bHbA1c target is 8%
  3. c HbA1c target is the general HbA1c target of 7%
  4. d HbA1c target based on average of personalised HbA1c targets
  5. e HbA1c target is the general HbA1c target of 7%