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Table 1 Inclusion/exclusion criteria

From: Local effects of acupuncture on the median and ulnar nerves in patients with carpal tunnel syndrome: a pilot mechanistic study protocol

Inclusion criteria Age: 18–75
Sex: M, F
CTS diagnosis: EMG at OHSU’s EMG lab within the past 2 years, meeting criteria for mild-to-moderate CTS
CTS symptoms: Present for at least 3 months [42]
EMG inclusion criteria: mild-moderate median entrapment neuropathy (CTS) defined as meeting any of the following 3 conditions [40, 41]:
1. Prolonged distal median sensory AND/OR motor latency
2. Reduced median sensory nerve action potential (SNAP) amplitude by no more than 50%
3. Amplitude of the compound muscle action potential (CMAP) recorded from abductor pollicis brevis (APB) > 50% of normal
Exclusion criteria Conditions in which acupuncture/electroacupuncture may be contraindicated:
- Coagulopathy/current anti-coagulation treatment
- Epilepsy
- Cardiac pacemaker
- Pregnancy
- Presence of any skin condition in the arm, such as dermatitis, bruises, other skin lesions
Conditions in which QST testing may be contraindicated:
- Significant cognitive impairment such as diagnosis of Alzheimer’s disease or mental retardation or any other condition interfering with alertness and/or attention
- Hospitalization for anxiety or depression in the past 3 months
- Current psychiatric diagnoses (other than anxiety or depression)
- Illicit drug use in the past month
- Current alcohol abuse (>  2 drinks/day)
- History of significant neurological disease which may affect sensation: strokes, multiple sclerosis, or spinal cord disorder
- Change in neuropathy medications within the past 2 months
- Change in opioids, benzodiazepines, selective serotonin reuptake inhibitors (SSRIs), or other sedating medications in the past 2 months
Conditions which predispose to generalized neuropathy:
- Diabetes mellitus
- Uncorrected hypothyroidism
- Past chemotherapy treatment
Other contraindications:
- History of wrist or elbow fracture, past arm trauma, loss of fingers, scarring
- History of carpal tunnel release surgery or any other surgery on the arm or shoulder
- History of arthritis in the hand and elbow
- Use of any investigational drugs within the previous 6 months
EMG exclusion criteria; presence of severe CTS, defined as:
1. Absent SNAP recorded from the second digit AND/OR:
2. The amplitude of the CMAP recorded from the ABP muscle is less than 50% of normal (<  2.5 mV) [40, 41]
Other EMG exclusion criteria:
• Presence of ulnar neuropathy, peripheral neuropathy, or radiculopathy
• Presence of Martin-Gruber anastomosis
Secondary exclusion criteria Following Week 1 baseline QST and NCS measurements:
- Severe CTS symptoms leading to inability to tolerate acupuncture or QST
- Inability to tolerate NCS or QST
- Failure to comply with QST due to inattentiveness, etc.
- Hyperalgesia or hypoalgesia on QST
- Presence of Martin-Gruber anastomosis
- Presence of severe CTS
- Pure motor median neuropathy
- Ulnar neuropathy
  1. CTS carpal tunnel syndrome, OHSU Oregon Health & Science University, QST quantitative sensory testing