Table 1 Inclusion criteria for TIC-TOC trial

Penetrating Torso Trauma:

• Penetrating trauma to the chest, abdomen, neck, pelvis, or thigh with at least one of the following:

 ◦ age-adjusted hypotension, or

 ◦ age-adjusted tachycardia despite adequate resuscitation fluids, or

 ◦ radiographic evidence of internal hemorrhage, or

 ◦ clinical suspicion of ongoing internal hemorrhage

Blunt Torso Trauma:

• Clinician suspicion of hemorrhagic blunt torso injury and at least one of the following:

 ◦ age-adjusted hypotension, or

 ◦ persistent age-adjusted tachycardia despite adequate resuscitation fluids

• Hemothorax on chest tube placement or imaging; or

• Clinical suspicion of hemorrhagic blunt torso injury and intraperitoneal fluid on abdominal ultrasonography (Focused Assessment with Sonography in Trauma; FAST); or

• Intra-abdominal injury on CT with either contrast extravasation or more than trace intraperitoneal fluid; or

• Pelvic fracture with contrast extravasation or hematoma on abdominal/pelvic CT scan with at least one of the following:

 ◦ age-adjusted tachycardia or

 ◦ age-adjusted hypotension

Head Trauma:

• GCS score 3 to 13 with associated intracranial hemorrhage on cranial CT scan