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Table 1 Inclusion criteria for TIC-TOC trial

From: Traumatic injury clinical trial evaluating tranexamic acid in children (TIC-TOC): study protocol for a pilot randomized controlled trial

Penetrating Torso Trauma: • Penetrating trauma to the chest, abdomen, neck, pelvis, or thigh with at least one of the following:  ◦ age-adjusted hypotension, or  ◦ age-adjusted tachycardia despite adequate resuscitation fluids, or  ◦ radiographic evidence of internal hemorrhage, or  ◦ clinical suspicion of ongoing internal hemorrhage Blunt Torso Trauma: • Clinician suspicion of hemorrhagic blunt torso injury and at least one of the following:  ◦ age-adjusted hypotension, or  ◦ persistent age-adjusted tachycardia despite adequate resuscitation fluids • Hemothorax on chest tube placement or imaging; or • Clinical suspicion of hemorrhagic blunt torso injury and intraperitoneal fluid on abdominal ultrasonography (Focused Assessment with Sonography in Trauma; FAST); or • Intra-abdominal injury on CT with either contrast extravasation or more than trace intraperitoneal fluid; or • Pelvic fracture with contrast extravasation or hematoma on abdominal/pelvic CT scan with at least one of the following:  ◦ age-adjusted tachycardia or  ◦ age-adjusted hypotension Head Trauma: • GCS score 3 to 13 with associated intracranial hemorrhage on cranial CT scan
  1. Abbreviations: CT computed tomography, GCS Glasgow Coma Scale, TOC-TOC Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children