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Table 2 Effect of early tranexamic acid on all-cause, cause-specific and time-specific mortality in postpartum and traumatic haemorrhage

From: Outcome measures in clinical trials of treatments for acute severe haemorrhage

Cause/time of death Postpartum haemorrhage Traumatic haemorrhageb All
(N = 14,923) (N = 13,484) (N = 28,407)
RR (95% CI) p value RR (95% CI) p value RR (95% CI) p value
All-cause 0.83 (0.66–1.04) 0.099 0.87 (0.80–0.94) < 0.001 0.86 (0.80–0.93) < 0.001
Cause-specific
 Haemorrhage 0.69 (0.53–0.90) 0.007 0.72 (0.63–0.83) < 0.001 0.72 (0.63–0.81) < 0.001
 Thrombosisa 1.15 (0.39–3.42) 0.803 0.56 (0.31–0.99) 0.043 0.65 (0.39–1.07) 0.090
 Other 1.35 (0.84–2.15) 0.213 0.99 (0.89–1.10) 0.867 1.01 (0.90–1.12) 0.908
Time-specific (hours from randomisation)
  < 48 0.74 (0.58–0.95) 0.015 0.83 (0.75–0.91) < 0.001 0.81 (0.74–0.89) < 0.001
 ≥ 48 1.81 (0.92–3.55) 0.080 0.94 (0.81–1.10) 0.457 0.98 (0.85–1.15) 0.844
  1. Includes patients treated within 3 h of delivery/injury only
  2. aIncludes stroke, myocardial infarction and pulmonary embolism
  3. bTime of death estimated using time and date of randomisation and date of death
  4. CI confidence interval, RR relative risk