Table 2 Table summarising all clinician-administered and self-administered scales used in the study. Study scales used in the anti-inflammatory treatment of depression study, their range, cutoff for study eligibility and rater identity
Scale name | Purpose of scale | Score range | Study cutoff | Rater |
|---|---|---|---|---|
Montgomery–Åsberg Depression Rating Scale (MADRS) | Detect the presence and severity of depressive symptoms | 0–60 (0–6 = normal/recovered; 7–19 = mild depression; 20–34 = moderate depression; and 35–60 = severe depression) | ≥ 26, or if Item 10’s (suicidal ideation) score ≥ 5 | Blinded study clinician |
Mini-International Neuropsychiatric Interview (MINI) | Fulfilment or non-fulfilment of minimum diagnostic criteria for Axis I neuropsychiatric disorders and antisocial personality disorder | N/A | Any current psychotic disorder | Blinded study clinician |
Columbia-Suicide Severity Rating Scale (C-SSRS) | Relative severity of suicidal ideation and behaviour in the last month and lifetime | 0–33, where the higher the number, the greater the severity of ideation and likelihood of suicidal behaviour | N/A | Blinded study clinician |
National Adult Reading Test (NART) | Predictor of IQ, independent of psychiatric morbidity | 0–50, with higher scores correlated with higher IQs | N/A | Blinded study clinician |
Clinical Global Impression scale (CGI) | Allows for quantification of patient morbidity (CGI-S), and progress and treatment response over time (CGI-I) | 2 scales of 0–7; in CGI-S, 0 is normal while 7 indicates complete disability; and in CGI-I, 0 indicates substantial improvement while 7 indicates severe exacerbation of symptoms | N/A | Blinded study clinician |
Functioning Assessment Short Test (FAST) | The extent of difficulty the participant has had in specific areas of everyday life in the specified timeframe | 0–72, where the higher the number, the more severe the difficulty in functioning | N/A | Blinded study clinician |
WHO-5 Well-Being Index | Estimates the participant’s well-being by gauging the proportion of time spent in a positive state of mind in the last 2 weeks | 0–100, where the higher the number, the greater the participant’s well-being | N/A | Self-administered |
Endicott Work Productivity Scale (EWPS) | Assessment of productivity when at work and record of hours worked | 0–100, where the higher the number, the poorer the participant’s productivity at work | N/A | Self-administered |
Work Limitation Questionnaire (WLQ-25) | Assessment of impairment to full functional capacity at work | 0–100, where the higher the number, the less able the participant is to meet the requirements of their work | N/A | Self-administered |
Sheehan Disability Scale (SDS) | The degree to which the participant has been impaired in work/school, social and family life due to disability | 3 scales from 0 to 10, considered independently or combined; and count of days unable to work or unproductive | N/A | Self-administered |
THINC-it® Perceived Deficits Questionnaire-5-D (PDQ-5-D) | Participant’s own recollection of cognitive difficulties in the past 7 days | 0–20, where the higher the number, the greater the perceived cognitive deficit; score can also be multiplied by 200 to give the same scoring range as the subsequent THINCit® tests | N/A | Self-administered |
THINC-it® Spotter | Test of attention and response speed | Overall score: 0–4000, where a higher number indicates greater ability in all measures; additionally, accuracy (range: 0–40) and speed (mean response time) are recorded | N/A | Self-administered |
THINC-it® Symbol Check | Test of working memory and attention | Overall score: 0–4000, where a higher number indicates greater ability in all measures; additionally, accuracy (count correct vs incorrect) and speed (mean response time) are recorded | N/A | Self-administered |
THINC-it® Codebreaker | Test of attention, perceptual speed, motor speed, visual scanning and memory | Overall score: 0–4000, where a higher number indicates greater ability in all measures; additionally, accuracy (count correct vs incorrect) and speed (mean response time, maximum 1 s) are recorded | N/A | Self-administered |
THINC-it® Trails | Test of visual search speed, scanning, speed of processing, mental flexibility and executive functioning | Overall score: 0–4000, where a higher number indicates greater ability in all measures; additionally, accuracy (count correct vs incorrect, error type) and speed (total completion time) are recorded | N/A | Self-administered |