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Table 2 Table summarising all clinician-administered and self-administered scales used in the study. Study scales used in the anti-inflammatory treatment of depression study, their range, cutoff for study eligibility and rater identity

From: Anti-inflammatory treatment of depression: study protocol for a randomised controlled trial of vortioxetine augmented with celecoxib or placebo

Scale name Purpose of scale Score range Study cutoff Rater
Montgomery–Åsberg Depression Rating Scale (MADRS) Detect the presence and severity of depressive symptoms 0–60 (0–6 = normal/recovered; 7–19 = mild depression; 20–34 = moderate depression; and 35–60 = severe depression) ≥ 26, or if Item 10’s (suicidal ideation) score ≥ 5 Blinded study clinician
Mini-International Neuropsychiatric Interview (MINI) Fulfilment or non-fulfilment of minimum diagnostic criteria for Axis I neuropsychiatric disorders and antisocial personality disorder N/A Any current psychotic disorder Blinded study clinician
Columbia-Suicide Severity Rating Scale (C-SSRS) Relative severity of suicidal ideation and behaviour in the last month and lifetime 0–33, where the higher the number, the greater the severity of ideation and likelihood of suicidal behaviour N/A Blinded study clinician
National Adult Reading Test (NART) Predictor of IQ, independent of psychiatric morbidity 0–50, with higher scores correlated with higher IQs N/A Blinded study clinician
Clinical Global Impression scale (CGI) Allows for quantification of patient morbidity (CGI-S), and progress and treatment response over time (CGI-I) 2 scales of 0–7; in CGI-S, 0 is normal while 7 indicates complete disability; and in CGI-I, 0 indicates substantial improvement while 7 indicates severe exacerbation of symptoms N/A Blinded study clinician
Functioning Assessment Short Test (FAST) The extent of difficulty the participant has had in specific areas of everyday life in the specified timeframe 0–72, where the higher the number, the more severe the difficulty in functioning N/A Blinded study clinician
WHO-5 Well-Being Index Estimates the participant’s well-being by gauging the proportion of time spent in a positive state of mind in the last 2 weeks 0–100, where the higher the number, the greater the participant’s well-being N/A Self-administered
Endicott Work Productivity Scale (EWPS) Assessment of productivity when at work and record of hours worked 0–100, where the higher the number, the poorer the participant’s productivity at work N/A Self-administered
Work Limitation Questionnaire (WLQ-25) Assessment of impairment to full functional capacity at work 0–100, where the higher the number, the less able the participant is to meet the requirements of their work N/A Self-administered
Sheehan Disability Scale (SDS) The degree to which the participant has been impaired in work/school, social and family life due to disability 3 scales from 0 to 10, considered independently or combined; and count of days unable to work or unproductive N/A Self-administered
THINC-it® Perceived Deficits Questionnaire-5-D (PDQ-5-D) Participant’s own recollection of cognitive difficulties in the past 7 days 0–20, where the higher the number, the greater the perceived cognitive deficit; score can also be multiplied by 200 to give the same scoring range as the subsequent THINCit® tests N/A Self-administered
THINC-it® Spotter Test of attention and response speed Overall score: 0–4000, where a higher number indicates greater ability in all measures; additionally, accuracy (range: 0–40) and speed (mean response time) are recorded N/A Self-administered
THINC-it® Symbol Check Test of working memory and attention Overall score: 0–4000, where a higher number indicates greater ability in all measures; additionally, accuracy (count correct vs incorrect) and speed (mean response time) are recorded N/A Self-administered
THINC-it® Codebreaker Test of attention, perceptual speed, motor speed, visual scanning and memory Overall score: 0–4000, where a higher number indicates greater ability in all measures; additionally, accuracy (count correct vs incorrect) and speed (mean response time, maximum 1 s) are recorded N/A Self-administered
THINC-it® Trails Test of visual search speed, scanning, speed of processing, mental flexibility and executive functioning Overall score: 0–4000, where a higher number indicates greater ability in all measures; additionally, accuracy (count correct vs incorrect, error type) and speed (total completion time) are recorded N/A Self-administered