Fig. 2

Standard Protocol Items: Recommendation for Interventional Trials (SPIRIT): the schedule of enrollment, interventions, and assessments. SPMSQ Short Portable Mental Status Questionnaire, FSS Fatigue Severity Scale, 9HPT 9-Hole Peg Test, T25FW Timed 25-foot walk, SDMT-O Symbol Digit Modalities Test–Oral, 6MWT 6-Minute walk test, MSQ Medical Symptoms Questionnaire, MFIS Modified Fatigue Impact Scale, MSQOL54 Multiple Sclerosis Quality of Life 54, FSMCF Fatigue Scale for Motor and Cognitive Function, MSIS v2 Multiple Sclerosis Impact Scale version 2, HADS Hospital Anxiety and Depression Scale, PSQI, PSS 10 Perceived Stress Scale 10, IPAQ-L International Physical Activity Questionnaire–Long, SF36 36-Item Short Form Health Survey, PDQ Perceived Deficits Questionnaire, MHI Mental Health Inventory, FFQ Food Frequency Questionnaire