Table 2 Demographics of respondents (n = 371)
Number of trials in which respondent has been involved a | Number of trials the respondent has been involved with that had a Data and Safety Monitoring Board (DSMB) monitoring the trial b | ||
Number of trials | n (%)q | Number of trials | n (%)q |
None 1 to 5 trials 6 to 10 trials 11 to 15 trials More than 15 trials Unknown A | 4 (1.1) 20 (5.4) 25 (6.7) 23 (6.2) 131 (35.3) 168 (45.3) | None 1 to 5 trials 6 to 10 trials 11 to 15 trials More than 15 trials UnknownB | 10 (2.7) 34 (9.2) 37 (10.0) 28 (7.5) 88 (23.7) 174 (46.9) |
Number of trials the respondent has been involved with that had some form of private industry sponsorship c | Primary profession by training d | ||
Number of trials | n (%)q | Main profession | n (%)q |
None 1 to 5 trials 6 to 10 trials 11 to 15 trials More than 15 trials UnknownC | 29 (7.8) 69 (18.6) 25 (6.7) 14 (3.8) 64 (17.3) 170 (45.8) | Mathematician/statistician/biostatistician Methodological scientist/research methodologist Physician Epidemiologist Research or clinical trial coordinator Ethics specialist Trialist Analyst Computer programmer Trial manager Trial monitor UnknownD | 156 (42.0) 21 (5.7) 10 (2.7) 5 (1.3) 3 (0.8) 2 (0.5) 2 (0.5) 1 (0.3) 1 (0.3) 1 (0.3) 1 (0.3) 168 (45.3) |
Usual work setting of respondents e | Other work settings of respondents f * | ||
Place of work | n (%)q | Other places of work | n (%)q |
University or academic institution Private or contracted research company Pharmaceutical company Government research group Hospital Government regulatory body Academic university hospital Medical device company Private practice Retired UnknownE | 123 (33.2) 28 (7.5) 17 (4.6) 13 (3.5) 10 (2.7) 5 (1.3) 3 (0.8) 1 (0.3) 1 (0.3) 1 (0.3) 169 (46.0) | Hospital University or academic institution Pharmaceutical company Private or contracted research company Government research group Medical or health clinic Government regulatory body Medical device company Private practice Consulting entity Data Safety Monitoring Board Health maintenance organization (research department) UnknownF | 36 (9.7) 35 (9.4) 18 (4.9) 15 (4.0) 15 (4.0) 12 (3.2) 11 (3.0) 7 (1.9) 4 (1.1) 1 (0.3) 1 (0.3) 1 (0.3) 268 (72.2) |
Roles respondents have taken on in relation to trial operation g* | Professional roles respondents have taken on h* | ||
Roles in relation to the trial | n (%)q | Professional roles | n (%)q |
Trial statistician Data Safety Monitoring Board member Trialist or investigator (i.e., co-investigator in a trial) Data analyst Principal investigator (PI) of a clinical trial Sponsor representative Funder representative Data manager Steering Committee Independent unblinded reporting Statistician to the DSMB Trial coordinator Data coordinator/manager Government regulator Consultant Unknown G | 161 (43.4) 136 (36.7) 88 (23.7) 68 (18.3) 30 (8.1) 26 (7.0) 18 (4.9) 11 (3.0) 11 (3.0) 9 (2.4) 7 (1.9) 4 (1.1) 3 (0.8) 3 (0.8) 171 (46.1) | Methodological scientist/research methodologist Epidemiologist Mathematician/statistician Data manager Computer programmer Research or clinical trial coordinator Computer scientist Ethics specialist Physician Information technologist Lawyer Medical laboratory technician Medical laboratory scientist Nurse or nurse practitioner Biochemist Engineer Regulator Teacher Therapist Trial management UnknownH | 89 (24.0) 63 (17.0) 48 (12.9) 36 (9.7) 35 (9.4) 12 (3.2) 10 (2.7) 10 (2.7) 9 (2.4) 6 (1.6) 2 (0.5) 1 (0.3) 1 (0.3) 1 (0.3) 1 (0.3) 1 (0.3) 1 (0.3) 1 (0.3) 1 (0.3) 1 (0.3) 211 (56.9) |