Table 4 Treatment characteristics of N-of-1 tests in developing countries
From: N-of-1 trials in the clinical care of patients in developing countries: a systematic review
Variable | Number (%) |
|---|---|
Type of medical intervention | |
Traditional medicine | 5 (83%) |
Modern medicine | 1 (17%) |
Number of planned treatment cycles | |
3 cycles | 6 (100%) |
Number of crossovers | |
2 | 6 (100%) |
Treatment length | |
≥ 2 weeks | 6 (100%) |
Washout | |
5–9 days | 4 (67%) |
2 days | 2 (33%) |
Number of trials blinded | 4 (67%) |
Outcome measurement (multiple answer) | |
Patient self-rated symptom score | 6 (100%) |
Other measurement tools or questionnaires | 5 (83%) |
Responder definition | |
P value < 0.05 | 4 (67%) |
Visual analogue scale (not statistical) difference specified | 2 (33%) |
Clinical (not statistical) difference specified | 2 (33%) |
Method of analysis | |
Pooled analysis (using methods other than Bayesian) | 2 (33%) |
Wilcoxon signed rank test/non-parametric | 1 (17%) |
Mean difference | 2 (33%) |
Paired t test | 4 (67%) |
Number of individuals who participated | 72 |
Proportion (%) of individuals completing the trial (completion rate) | 67 (93) |
Proportion (%) of post-N-of-1 RCTs decisions which favor trial results | 46 (69) |