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Table 2 Required duration of enrollment to achieve > 80% power

From: Improving outcomes after pediatric cardiac arrest – the ICU-Resuscitation Project: study protocol for a randomized controlled trial

 

Duration of enrollment (years)a

Trial design

 Parallel

NAb

 Traditional stepped-wedge

  6-month transition

6

  3-month transition

5.25

 Hybrid stepped-wedge

  6-month transition

4.75

  3-month transition

4.5

  1. aDuration of enrollment is the approximate number of years required to achieve > 80% power to detect an increase from 40% to 51% in the rate of survival with favorable neurologic outcome
  2. bIn this context, a parallel design cannot achieve 80% power, regardless of the duration of enrollment