Table 1 Follow-up periods for all study endpoints
Endpoint | Beginning of follow-up | End of follow-up/censoring event (soonest event applies, except where specified) |
|---|---|---|
Primary | ||
 VARI | Randomisation | ICU discharge/death/transfer or 90 days |
Secondary | ||
 Microbiologically confirmed VARI | Randomisation | ICU discharge/death/transfer or 90 days |
 Clinical and microbiologically confirmed VAP | Randomisation | ICU discharge/death/transfer or 90 days |
 Intubated days not receiving antibiotics | Randomisation | ICU discharge/death/transfer or 90 days |
 Incidence of HAI | Randomisation | Extubation/death/transfer/discharge from ICU or 90 days |
 Days ventilated/in ICU | Randomisation | ICU discharge, death, transfer |
 Cost of ICU stay | ICU admission | ICU discharge/death/transfer |
 Cost of antibiotics in ICU stay | ICU admission | ICU discharge/death/transfer |
 Cost of hospital stay | Hospital admission | Hospital discharge |
 28-Day mortality | Randomisation | 28 Days after randomisation |
 90-Day mortality | Randomisation | 90 Days after randomisation |
 ICU mortality | Randomisation | Discharge from ICU or death/palliative discharge from ICU |
 Hospital mortality | Randomisation | Discharge from hospital or death/palliative discharge from hospital |