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Table 2 Dose cohort levels for the phase Ib dose escalation phase

From: SPIRE – combining SGI-110 with cisplatin and gemcitabine chemotherapy for solid malignancies including bladder cancer: study protocol for a phase Ib/randomised IIa open label clinical trial

Dose level

SGI-110 dose, per treatment cycle

−1

10 mg/m2, daily, on days 1–5

1

20 mg/m2, daily, on days 1–5

2

30 mg/m2, daily, on days 1–5

3

45 mg/m2, daily, on days 1–5

4

60 mg/m2, daily, on days 1–5