From: SPIRE – combining SGI-110 with cisplatin and gemcitabine chemotherapy for solid malignancies including bladder cancer: study protocol for a phase Ib/randomised IIa open label clinical trial
Dose level
SGI-110 dose, per treatment cycle
−1
10 mg/m2, daily, on days 1–5
1
20 mg/m2, daily, on days 1–5
2
30 mg/m2, daily, on days 1–5
3
45 mg/m2, daily, on days 1–5
4
60 mg/m2, daily, on days 1–5