Cerebral microembolism in the critically ill with acute kidney injury (COMET-AKI trial): study protocol for a randomized controlled clinical trial

Table 1 Study measures at each visit

	Visit 1: screening	Visit 2: baseline neurocognitive examinations	Visit 3: Doppler measurement CRRT	Visit 4: randomization	Visit 5: Doppler measurement IRRT or CRRT	Visit 6: follow-up neurocognitive examinations
Duration of visit	30 min	60–120 min	90 min	30 min		60–120 min
Recruitment	X
Consent Form	X
Inclusion/exclusion	X
Medical history	X
TTE/TEE	X
Assess vital signs		X	X	X	X	X
External randomization				X
Clinical examination		X				X
Doppler examination			X		X
MRI		X				X
CAM-ICU		X				X
RASS		X				X
MoCA		X				X
SF-36^a						X

^aAfter 6 and 12 months. CAM-ICU Confusion Assessment Method for the Intensive Care Unit, CRRT continuous renal replacement therapy, IRRT intermittent renal replacement therapy, MoCA Montreal Cognitive Assessment, SF-36 Short Form (36) Health Survey, MRI, magnetic resonance imaging, RASS Richmond Agitation and Sedation Scale, TEE transesophageal echocardiography, TTE transthoracic echocardiography

ISSN: 1745-6215