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Fig. 1 | Trials

Fig. 1

From: Restrictive Versus Massive Fluid Resuscitation Strategy (REFILL study), influence on blood loss and hemostatic parameters in obstetric hemorrhage: study protocol for a randomized controlled trial

Fig. 1

SPIRIT flow diagram. *t1 at 500–750 cm3, resuscitation within randomized protocol starts, blood withdrawal. **t2, 45–60 min after t1, second blood withdrawal. ***t3 12–18 h after t1, third blood withdrawal. **** i.e. maternal age, ethnic background, parity (nulliparous or multiparous), gestational age, obstetric history, length, weight, use of oxytocin, mode of delivery (vaginal delivery, instrumental delivery, or Cesarean section), delivery of placenta (spontaneous or manual), life birth, and birth weight. ***** All different treatments to resolve the underlying cause of PPH given to the patient will be registered, intensive care admittance, the need of four or more units of packed cells, embolization, and hysterectomy, laboratory results at t1, t2, and t3

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