Table 4 Contraindicated drugs during clinical trial

1

Other beta-blockers except the study medication

2

Steroid medication (ACTH or corticosteroid). Locally applied drugs are allowed.

3

Non-steroidal anti-inflammatory drugs. They are allowed only for shor term use (≤7 days) according to the examiner’s decision, while their usage is absolutely prohibited 3 days before the scheduled visits. Low-dose aspirin (30 to 300 mg daily) for cardiovascular diseases is allowed.

4

Estrogen medications. If necessary, low-dose hormonal therapy can be continued for therapeutic purpose at the same dose during the study period

5

Sympathomimetic drugs such as catecholamines

6

Anti-psychotics:

MAO inhibitors, anti-depressants (tri- and tetra-cyclic classes, selective serotonin reuptake inhibitors including lithium)

Sedatives and anti-anxiolytics (benzodiazepines and their antagonists, barbiturates, hypnotics such as zolpidem) can be intermittently used according to the physician's decision, while their usage is absolutely prohibited 7 days before the scheduled visits

7

Immunosuppressants

8

Thyroid hormones. If necessary, thyroid hormonal therapy can be prescribed for therapeutic purpose at the same dose during the study period