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Table 6 Operating characteristics for detecting differences in the primary endpoint

From: A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial

Total N
(intervention + control)
Ratio Type 1 error Proportion of patients achieving a reduction in ICS or OCS Power
Control Intervention Difference
400 (320 + 80) 4:1 0.05 10% 26% 16% 83%
300 (240 + 60) 4:1 0.05 10% 29% 19% 83%
200 (160 + 40) 4:1 0.05 10% 34% 24% 83%
  1. Assumes a 20% drop out rate
  2. ICS inhaled corticosteroid, OCS oral corticosteroid