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Table 2 Biomarker-based therapy adjustment

From: A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial

Score Corticosteroid dose step-wise adjustment Follow-up
0 Reduce treatment 1 step If score remains 0 on low-dose corticosteroid – type 2 (T2)-low severe asthma
1 Maintain current treatment Adjust as necessary based on follow-up scores
2 Increase treatment 1 step If score remains 2 despite maximal inhaled corticosteroid therapy necessitating systemic steroid therapy – T2-high severe asthma
  1. All therapeutic adjustments will be automatically calculated and advised by the electronic case report form (e-CRF)
  2. Corticosteroid treatment adjustment based on composite biomarker score