Table 1 Inclusion and exclusion criteria

1. Aged 18–75 years

2. Written informed consent provided

3. Patients with a clinical diagnosis of chronic stable angina who fulfill one of the following conditions:

 a. Symptoms that support the diagnosis of chronic angina, and/or a history of an abnormal exercise response limited by angina, and/or electrocardiographic changes

 b. A history of myocardial infarction and ST-T changes

 c. Stenosis greater than 50% in at least one major epicardial coronary artery, as shown by coronary angiography or computed tomographic angiography

 d. Coronary heart disease confirmed by radionuclide angiocardiography

4. Patients with moderate angina pectoris, which is defined as grade II or III on the Canadian Cardiovascular Society Angina Grading Scale

1. Patients with severe complications that would complicate the condition, as assessed by the investigator, including liver or renal dysfunction, severe cardiopulmonary dysfunction, pulmonary hypertension, chronic obstructive pulmonary disease, a history of epilepsy, or cerebral hemorrhage

2. Patients who experienced myocardial infarction or who were classified as grade IV on the Canadian Cardiovascular Society Angina Grading Scale within the preceding 3 months

3. Patients with chest pain that is caused by any other disease (e.g., acute myocardial infarction, severe neurosis, menopausal syndrome, or hyperthyroidism)

4. Patients with a history of drug-induced bleeding or a history of bleeding caused by warfarin

5. Patients with a history of hematopoietic disorder

6. Patients who have had surgery within the previous 4 weeks or who have a hemorrhagic tendency

7. Women who are pregnant or lactating or who have a positive pregnancy test, or women who have a menstrual period at baseline

8. Patients who are participating in other trials or who have participated in other trials within the past 3 months

9. Patients with a history of allergy or with a known or suspected allergy to the study drug

10. Patients with a known or suspected history of alcohol or drug abuse within the past 2 years

11. Patients with a mental disorder

12. Family members or relatives of the study center staff

13. Inability to adhere to study procedures