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Table 2 Endpoints

From: Low tidal volume mechanical ventilation against no ventilation during cardiopulmonary bypass heart surgery (MECANO): study protocol for a randomized controlled trial

  Endpoint
Primary All-cause mortality
Early respiratory failure (PaO2/FiO2 ratio <200 in the first hour after transfer to ICU after surgery)
Late respiratory failure (heavy oxygenation support (non-invasive ventilation, high-flow oxygen or mechanical ventilation) 2 days after surgery)
Ventilator-acquired pneumonia
Early pneumonia (early or ventilator-acquired)
Secondary All-cause in-hospital mortality
Early respiratory failure
Heavy oxygenation support
Pneumonia
Length of stay in the ICU (days) after the initial cardiac surgery)
Length of stay in the hospital (days) after the initial cardiac surgery
Cost of hospitalization (euros)
Other Revision surgery (requirement for any revision cardiac surgery after the initial surgery)
Pneumothorax (diagnosed on chest x-ray or  CT-scan occurring after the initial surgery)
Postoperative bleeding (mL)
Cardiopulmonary bypass duration (minutes)
Red blood cells transfusion (units)
  1. PaO2/FiO2 partial pressure of oxygen/fraction of inspired oxygen; CT-scan computerized tomography scanner