Primary outcome
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Hamilton Rating Scale for Depression (HRSD)
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24-Item instrument with overall score range of 0–76
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Measured at screening phase as baseline, end of each acute treatment week, and end of every 4 weeks during the follow-up phase
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Secondary outcomes
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Montgomery-Asberg Depression Rating Scale (MADRS)
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10-Item instrument with overall score range of 0–60
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Measured at screening phase as baseline, end of each acute treatment week, and end of every 4 weeks during the follow-up phase
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Beck Depression Inventory (BDI)
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21-Item self-report test with overall score range of 0–63
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Measured at screening phase as baseline, end of each acute treatment week, and end of every 4 weeks during the follow-up phase
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Beck Scale for Suicide Ideation (BSS)
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21-Item self-report test with overall score range of 0–38 with last 2 items not counted in scoring
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Measured at screening phase as baseline, end of each acute treatment week, end of each taper week and week 4, and end of every 4 weeks during the follow-up phase
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Veterans RAND 36-Item Health Survey (VR-36)
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A self-administered survey consisting of two parts, i.e. Physical Component Summary (PCS, standardized score range of 0–100) and Mental Component Summary (MCS, standardized score range of 0–100)
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Measured at screening phase as baseline, end of the acute treatment phase, and end of the follow-up phase
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Neuropsychological Battery
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A cognitive function test including measures of executive function, attention, memory, visuospatial ability, processing speed, psychomotor function, and premorbid intelligence
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Measured at screening phase as baseline, end of the acute treatment phase, and end of the follow-up phase
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