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Table 3 Multivariable determinants of adhering to medication in the Colitis Once Daily Asacol (CODA) trial

From: The use of randomisation-based efficacy estimators in non-inferiority trials

Purpose Variable Adjusted odds ratio 95% Confidence interval p value
Lower Upper
Associated with disease status at 12 months (relapsed/still in remission) Intervention (OD arm compared to TDS arm) 2.61 0.75 9.03 0.131
Age at baseline (≥65 years compared to <65 years) 2.42 0.27 21.70 0.430
Length of remission (≥12 months compared to <12 months) 1.05 0.29 3.75 0.940
Endoscopy findings at baseline (non-normal compared to normal) 0.31 0.10 1.01 0.053
Associated with adherence to study medication Smoking status at baseline (current smoker compared to non-smoker) 1.31 0.25 6.79 0.076
Smoking status at baseline (ex-smoker compared to non-smoker) 11.46 1.40 94.01
  1. OD once daily, TDS three times daily