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Table 1 Estimated differences between patients with (n = 190) and without (n = 74) follow-up data 

From: Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study

Predictor

Summary

Difference between patients with versus without follow-up (95% CI)a

p Value

Baseline WMH volume, ml, mean ± SD

22.0 ± 24.8

−4.1 (−10.8 to 2.7)

0.23

Age, years, mean ± SD

65.3 ± 11.3

5.7 (−8.8 to −2.6)

0.0004

MAP, mmHg, mean ± SD

102.8 ± 15.4

0.50 (−3.61 to 4.61)

0.81

PP, mmHg, mean ± SD

63 ± 20.7

−0.45 (−5.88 to 4.98)

0.87

Hypertension, n (%)

142 (74.7)

8.5% (−3.9 to 20.9%)

0.16

Stroke subtype lacunar, n (%)

87 (45.8)

3.9% (−9.4 to 17.2%)

0.57

Smoker (current and recent ex-smokers), n (%)

73 (38.4)

−1.9% (−15.1 to 11.4%)

0.78

Diabetes, n (%)

21 (11.1)

−1.1% (−9.8 to 7.8%)

0.80

Hyperlipidaemia, n (%)

116 (61.1)

0.2% (−12.9 to 13.4%)

0.97

Fazekas score = 0, n (%)

8 (4.2)

1.5% (−3.2 to 6.2%)

Overall p value = 0.049

Fazekas score = 1, n (%)

17 (9.0)

−1.9% (−10.0 to 6.3%)

Fazekas score = 2, n (%)

70 (36.8)

8.5% (−3.9 to 20.8%)

Fazekas score = 3, n (%)

24 (12.6)

3.2% (−5.0 to 11.3%)

Fazekas score = 4, n (%)

29 (15.3)

8.5% (−0.8 to 16.2%)

Fazekas score = 5, n (%)

17 (9.0)

−8.6% (−18.2 to 1.0%)

Fazekas score = 6, n (%)

25 (13.2)

−11.2% (−22.1 to 0.3%)

  1. Abbreviations: MAP Mean arterial pressure, PP Pulse pressure, WMH White matter hyperintensity
  2. a Estimated difference between patients with and without follow-up WMH volume (difference in means for baseline WMH, age, MAP, PP and difference in percentage for other predictors). A positive number indicates that patients with follow-up had a higher mean or larger proportion