Drug class | Agent | Wash-out |
---|---|---|
CYP3A4 inducers | ||
Antibiotics | All rifamycin agents (e.g., rifampicin, rifabutin, rifapentine) | 14 days |
Anticonvulsants | Phenytoin, carbamazepine, barbiturates (e.g., phenobarbital) | |
Antiretrovirals | Efavirenz, nevirapine | |
Glucocorticoids (oral) | Cortisone (>50 mg), hydrocortisone (>40 mg), prednisone (>10 mg), methylprednisone (>8 mg), dexamethasone (>1.5 mg) | Not Applicable |
Others | St. John’s wort (Hypericum perforatum), modafinil | Not Applicable |
CYP3A4 inhibitors | ||
Antibiotics | Clarithromycin, erythromycin, troleandomycin | 7 days |
Antifungals | Itraconazole, ketoconazole, fluconazole (>150 mg/d), voriconazole | |
Antiretrovirals, protease inhibitors | Delavirdine, nelfinavir, amprenavir, ritonavir, indinavir, saquinavir, lopinivir | |
Calcium channel blockers | Verapamil, diltiazem | |
Antidepressants | Nefazodone, fluvoxamine | |
GI agents | Cimetidine, aprepitant | |
Others | Grapefruit, grapefruit juice | |
Amiodarone | 6 months | |
Miscellaneous | ||
Antacids | Mylanta®, Maalox®, Tums®, Rennie® | 1 h before and after dosing |
Herbal or dietary supplements | Ginkgo biloba, grape seed, valerian, ginseng, echinacea, evening primrose oil | 14 days |