Measurement | Enrollment | Baseline | 6Â months | 12Â months | 18Â months | Other |
---|---|---|---|---|---|---|
Enrollment | ||||||
 Recruitment and screening | X |  |  |  |  |  |
 Information and consent | X |  |  |  |  |  |
Primary outcome | Â | Â | Â | Â | Â | Â |
 MRI CSA of quadriceps femoris |  | X | X | X | X |  |
Secondary outcomes | ||||||
 Thigh isometric peak torque |  | X | X | X | X |  |
 Thigh isokinetic peak torque |  | X | X | X | X |  |
 Thigh power |  | X | X | X | X |  |
 30-second chair-stand |  | X | X | X | X |  |
 Muscle biopsy |  | X |  | X |  |  |
 Body composition (DXA) |  | X | X | X | X |  |
 Bone mineral density (DXA) |  | X |  | X |  |  |
 Gut microbiome |  | X | X | X |  |  |
 Fecal metabolome |  | X | X | X |  |  |
 Plasma metabolome |  | X | X | X |  |  |
 Acute muscle FSR |  | X |  | X |  |  |
Tertiary outcomes | ||||||
 Blood samples |  | X | X | X | X |  |
 Anthropometry |  | X | X | X | X |  |
 Hand grip strength |  | X | X | X | X |  |
 400-m gait speed |  | X | X | X | X |  |
 SF-36 and PSQI |  | X |  | X |  |  |
 Activity monitoring |  | X | X | X | X |  |
 Registration of food consumption |  | X |  | X |  | At week 6 |
 Sensory questionnaires |  |  | X | X |  | Weekly for 0–3 months |
 Satisfaction with Food-related Life scale |  | X | X | X |  |  |
 Oral glucose tolerance test |  | X |  | X |  |  |
 Qualitative interview |  | X |  |  | X |  |
 Questionnaire on food habits |  | X |  |  |  |  |
 Life story interviews |  |  |  |  |  | Ad hoc |
 Ethnographic fieldwork |  |  |  |  |  | Ad hoc |