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Fig. 1 | Trials

Fig. 1

From: Endothelial Dysfunction in Resuscitated Cardiac Arrest (ENDO-RCA): safety and efficacy of low-dose prostacyclin administration and blood pressure target in addition to standard therapy, as compared to standard therapy alone, in post-cardiac arrest syndrome patients: study protocol for a randomized controlled trial

Fig. 1

A systems biology perspective on vascular homeostasis in critical illness. Schematic illustration of the changes in the vascular system (circulating blood, vascular endothelium) with increasing disease (ischemia-reperfusion, trauma, sepsis, etc.) severity and sympathoadrenal activation (circulating catecholamines) evaluated by plasma-based (APTT, INR, PT) and functional whole blood-based (TEG) coagulation tests. Progressive endothelial activation and damage is accompanied by concurrent progressive hypocoagulability in the circulating blood. We infer (Johansson and Ostrowski) that the circulating catecholamine level dose-dependently promotes a switch from hyper- to hypocoagulability and hyperfibrinolysis in the blood to keep the progressively more procoagulant microvasculature open. From Johansson & Ostrowski [22]

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Trials

ISSN: 1745-6215