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Table 1 Criteria for identifying clinical trials that may benefit from accurate determination of doses administered

From: Biases affecting injected doses of an experimental drug during clinical trials

1 Studies to determine a drug’s absolute clearance or volume parameters
2 Studies in which a drug is administered intravenously
3 Studies using a drug not manufactured according to industrial standards
4 Studies on peptides, proteins or other complex biological agents
5 Studies using immunologically based analytical methods
6 Studies using a parallel-group design, with qualitatively different treatments administered to each group