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Table 4 Logistic regression models of run-in failure: full factorial study females

From: Randomized controlled trials: who fails run-in?

  Unadjusted OR (95 % CI)a p Final model: adjusted OR (95 % CI) C index = 0.62 p Final model + perceived toxicity adjusted OR (95 % CI)b C index = 0.66 p
Total participants    N = 301   N =301  
Race   0.06     
 White Reference      
 Black 0.92 (0.34–2.52)      
 Other 2.85 (0.50–16.13)      
Unknown/refused 4.75 (1.38–16.38)      
Hispanic ethnicity   0.05     
 No Reference      
 Yes 3.07 (0.98–9.59)      
Marital status   0.04     
 Married/cohabitating Reference      
 Single 1.95 (1.04–3.66)      
Education   0.08     
 Did not graduate high school 2.75 (1.05–7.23)      
 Graduated high school 1.69 (0.79–3.63)      
 Any college education Reference      
Smoking status   0.07     
 Never Reference      
 Former 1.80 (0.91–3.56)      
 Current 2.55 (1.06–6.17)      
Number of prescription medications   0.03   0.03   0.03
 0 Reference   Reference   Reference  
 1 0.43 (0.14–1.30)   0.43 (0.14–1.30)   0.40 (0.13–1.26)  
 2 0.21 (0.05–0.87)   0.21 (0.05–0.87)   0.21 (0.05–0.87)  
 3+ 0.99 (0.41–2.39)   0.99 (0.41–2.39)   0.97 (0.39–2.38)  
Experienced muscular pain in last year   0.07     
 None Reference      
 Some 0.39 (0.11–1.31)      
 Severe 3.66 (0.79–16.96)      
Experienced muscular weakness in last year   0.10     
 None/some Reference      
 Severe 5.32 (0.73–38.71)      
Refused any questions during enrollment self-administered questionnairesc   0.03     
 No Reference      
 Yes 2.41 (1.11–5.27)      
Had a perceived toxicity during run-in       0.001
 No      Reference  
 Yes      12.26 (2.79–54.00)  
  1. aIncluded were all variables that had p < 0.1 from Table 1 and baseline factors from Table 2
  2. bFinal model plus perceived toxicity, the post-enrollment factor from Table 2
  3. cNot a priori potential predictors