Table 4 Mean and standard deviation (SD) on cognitive tests at baseline, 12Â months, and change over time
| Â | Placebo | Simvastatin | Effect size | |||||
|---|---|---|---|---|---|---|---|---|
Baseline | 12Â months | Change | Baseline | 12Â months | Change | |||
NADIID | ||||||||
|  | Memory for Objects test | 5.7 (2.3) | 4.9 (2.6) | −0.8 (1.2) | 4.0 (2.4) | 5.3 (2.7) | 1.3 (1.0) | 1.0 (0.4, 1.6) |
Selective Attention Cancellation Test | ||||||||
|  | Overall score | 17.0 (9.3) | 18.8 (11.6) | 1.8 (14.1) | 25.3 (25.0) | 21.7 (8.4) | −3.7 (22.6) | −0.4 (−2.1, 1.3) |
CANTAB pattern recognition memory | ||||||||
|  | % Correct | 61.5 (23.5) | 67.3 (17.4) | 5.8 (6.7) | 56.6 (12.3) | 57.0 (12.2) | 0.4 (13.4) | −0.9 (−1.9, 0.1) |
Cats and Dogs switching condition | ||||||||
|  | Time taken | 58.8 (36.3) | 47.0 (31.5) | −11.8 (26.3) | 40.5 (22.0) | 44.0 (10.9) | 3.5 (27.4) | 0.05 (−1.3, 1.4) |
|  | Number of errors | 4.1 (5.3) | 7.0 (8.2) | 2.9 (8.6) | 11.0 (7.6) | 7.8 (7.5) | −3.3 (6.5) | –a |
Tower of London Test (revised for learning disabilities) | ||||||||
|  | Total score | 21.7 (8.5) | 24.8 (13.6) | 3.1 (11.1) | 20.7 (8.0) | 20.3 (11.7) | −0.3 (18.4) | −0.7 (−2.3, 0.86) |
Cued Recall Test | ||||||||
|  | Total score | 34.1 (4.5) | 28.7 (13.0) | −5.4 (12.7) | 21.2 (12.7) | 12.8 (14.2) | −8.3 (13.9) | –a |
Category Fluency Test | ||||||||
|  | Number correct | 12.1 (4.2) | 9.2 (3.9) | −2.9 (4.4) | 8.0 (4.2) | 8.2 (6.1) | 0.2 (3.5) | 0.3 (−1.1, 1.7) |
|  | Number repeated | 0.7 (1.1) | 1.0 (1.1) | 0.3 (0.9) | 2.6 (1.7) | 1.6 (1.1) | −1.0 (1.2) | 0.5 (−0.2, 1.3) |
|  | Number of errors | 0.3 (0.5) | 0.1 (0.3) | −0.2 (0.7) | 0.0 (0.0) | 0.2 (0.5) | 0.2 (0.5) | –a |
Story Recall Test | ||||||||
|  | Free recall | 5.8 (3.7) | 3.6 (3.3) | −2.1 (3.2) | 5.0 (6.3) | 3.0 (4.2) | −2.0 (3.7) | −0.4 (−1.2, 0.4) |
|  | Cued recall | 4.4 (2.7) | 3.9 (3.0) | −0.5 (2.9) | 2.4 (4.3) | 2.6 (3.7) | 0.2 (2.3) | −0.6 (−1.8, 0.7) |