Comparing endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) versus fine needle biopsy (FNB) in the diagnosis of solid lesions: study protocol for a randomized controlled trial

Table 1 Study schedule for data collection

Item	Interview 1	Interview 2	Interview 3	Interview 4
Item	1-0 week before EUS	0-1 week after EUS	12 weeks ± 5 days after EUS	48 weeks ± 5 days after EUS
Informed content	X
Inclusion criteria	X
Patient characteristics	X
Blood routine tests	X	X
Coagulation routine tests¹	X
Blood biochemistry tests²	X	X
Blood tumor markers tests³	X		X	X
Complications		X	X	X
Clinical signs⁴	X	X	X	X
Imaging examination	X	X	X	X
Cytology examination		X		X
Pathology examination		X		X
Surgical-pathological examination		X	X	X
Therapies		X	X	X

¹Coagulation routine tests: prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen, INR
²Blood biochemistry tests: AST, ALT, BUN, Cr, ALP, lipase, amylase
³Blood tumor marker tests: CEA, CA19-9, CA72-4, AFP, SSC, NSE
⁴ Clinical signs include pain, weight loss, cachexia, etc.

ISSN: 1745-6215