Study | Real-world data source | % ineligibilitya | Key differences (ineligible versus eligible patients) | Main author conclusionsb |
---|---|---|---|---|
Cardiology | ||||
Bahit et al., 2003 [16] | MC-PR | 33.6 | Older, more females/previous MI, lower ASA use, longer LOS | Different |
Bosch et al., 2008 [19] | SC-PR | 41.2 | Older, higher risk profile | Different |
Collet et al., 2003 [53] | SC-PR | 34.0 | Older, more females, higher risk score, fewer in-hospital procedures | NE |
Costantino et al., 2009c [21] | SC-PR | 66.2 | ND | Different |
Fortin et al., 2006 [55] | MC-PR | 1.4–65.5 | ND | NE |
Koeth et al., 2009 [34] | MC-PR | 46.4 | Older, more females, more diabetes/hypertension, less guideline-recommended treatment | Different |
Krumholz et al., 2003 [56] | MC-PR | 84.5 (NRMI) | ND | Similar |
90.6 (CCP) | ||||
Lenzen et al., 2005 [35] | MC-PR | 61.6 | Older, more females, more co-morbid hypertension/ACS/renal impairment, less guideline-recommended treatment at baseline | Different |
Masoudi et al., 2003 [36] | ID | 67.0 | ND | Different |
Steg et al., 2007 [40] | MC-PR | 33.6 | Older, history of MI, diabetes, TIA, PAD, and CABG, less guideline-recommended treatment/procedures, high risk score | Different |
Uijen et al., 2007c [44] | MC-PR | 53.0 | ND | Different |
Mental health | ||||
Blanco et al., 2008 [18] | GP | 75.8 | ND | Different |
Goedhard et al., 2010 [26] | SC-PR | 69.8 | Older, more Axis II personality disorders | Different |
Hoertel et al., 2013 [28] | GP | 58.2 (bipolar) | ND | Different |
55.8 (mania) | ||||
Keitner et al., 2003 [32] | SC-PR | 85.5 | ND | Different |
Khan et al., 2005 [33] | GP | 98.2 | ND | Different |
Rabinowitz et al., 2003c [59] | MC-PR | 33.0 | ND | Similar |
Seemuller et al., 2010 [61] | MC-PR | 69.0 | Younger, trend to younger age at disease onset | Similar |
Storosum et al., 2004 [41] | SC-PR | 83.8d | ND | Different |
Surman et al., 2010c [42] | SC-PR | 61.0 | More lifetime co-morbidity, lower overall functioning/SES | Different |
Talamo et al., 2008 [63] | SC-PR | 77.6 | Few differences | Similar |
van der Lem et al., 2011 [64] | SC-PR | 75.5–81.2e | ND | NE |
Wisniewski et al., 2009 [47] | MC-PR | 77.8 | Older, less educated, more black/Hispanic, longer disease duration, history of suicide and substance abuse, more atypical features | Different |
Zarin et al., 2005c [49] | MC-PR | 55.0 (bipolar) 38.0 (schizo-phrenia) | More co-morbidity, lower global functioning, greater use of antipsychotic medication | Different |
Zetin and Hoepner, 2007 [50] | SC-PR | 91.4 | ND | Different |
Zimmerman et al., 2004 [51] | SC-PR | 65.8 | ND | Different |
Oncology | ||||
Clarey et al., 2012 [20] | SC-PR | 31.0–76.0 | ND | Different |
Filion et al., 2012 [54] | SC-PR | –f | ND | Similar |
Fraser et al., 2011c [25] | MC-PR | 14.9 | ND | Different |
Mengis et al., 2003c [38] | SC-PR | 87.0 | ND | Different |
Mol et al., 2013 [58] | MC-PR | 21.5 | Worse performance status, higher alkaline phosphatase, less primary tumor resection | Similar |
Somer et al., 2008 [39] | SC-PR | 71.0 | ND | Different |
Terschüren et al., 2010 [43] | MC-PR | 35.9 (HL) | ND | Different |
70.4 (hgNHL) | ||||
Vardy et al., 2009 [46] | MC-PR | 65.0–72.0 | ND | Different |