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Fig. 2 | Trials

Fig. 2

From: Effect of a high-dose target-controlled naloxone infusion on pain and hyperalgesia in patients following groin hernia repair: study protocol for a randomized controlled trial

Fig. 2

Day 1/2 test-algorithm with superimposed naloxone plasma-concentration curves. Mean plasma-concentration (red) with 95 % CI (dashed black lines) during a 3-step target-controlled infusion. Naloxone is given at Step 1 with 0.25 mg/kg, Step 2 0.75 mg/kg and Step 3 2.25 mg/kg. Yellow timeline columns represent ratings with Clinical Opiate Withdrawal Scale (COWS) and blue columns indicate sensory testing (pain during rest, movement and 100 kPa pressure; pressure algometry; secondary hyperalgesia area). BL, baseline assessments (−20 minutes to −8 minutes); S1, Step 1 assessments (15 minutes to 25 minutes); S2, Step 2 assessments (39 minutes to 49 minutes); S3, Step 3 assessments (65 minutes to 75 minutes)

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Trials

ISSN: 1745-6215