Table 4 Results of mixed model for repeated measures (MMRM) analysis of per-protocol set (PPS)

FSS

A

4.70 (1.22)

3.38 (1.10)

0.017

−0.45 (−0.84, −0.07)

3.34 (1.17)

0.074

−0.36 (−0.75, 0.03)

B

4.74 (1.09)

3.58 (1.12)

0.090

−0.33 (−0.71, 0.04)

3.51 (1.19)

0.230

−0.26 (−0.64, 0.12)

C

4.52 (1.26)

4.47 (1.18)

-

-

4.24 (1.22)

-

-

SRI-short form

A

62.59 (17.77)

42.21 (14.18)

0.039

−5.92 (−11.58, −0.27)

42.28 (14.33)

0.063

−5.69 (−11.64, 0.26)

B

55.50 (14.23)

42.10 (13.66)

<0.001

−9.22 (−14.69, −3.76)

39.81 (13.55)

<0.001

−10.34 (−16.10, −4.58)

C

59.26 (18.34)

56.47 (18.03)

-

-

56.67 (20.11)

-

-

BDI

A

16.59 (8.60)

9.02 (6.92)

0.338

−1.39 (−3.82, 1.04)

9.64 (6.39)

0.386

−1.35 (−3.88, 1.18)

B

15.12 (7.67)

8.88 (7.66)

0.086

−2.14 (−4.54, 0.25)

7.89 (7.15)

0.018

−2.92 (−5.41, −0.43)

C

14.91 (6.78)

13.36 (6.39)

-

-

14.00 (8.42)

-

-

NRS

A

6.57 (1.42)

4.42 (1.98)

<0.001

−1.01 (−1.54, −0.48)

4.77 (2.22)

0.006

−0.76 (−1.33, −0.20)

B

6.53 (1.28)

4.52 (1.70)

<0.001

−0.98 (−1.50, −0.46)

4.51 (1.95)

<0.001

−0.90 (−1.46, −0.34)

C

6.47 (1.38)

6.53 (1.36)

-

-

6.38 (1.69)

-

-

EQ-5D

A

0.84 (0.10)

0.91 (0.11)

0.948

0.00 (−0.04, 0.03)

0.92 (0.11)

0.785

0.01 (−0.03, 0.05)

B

0.87 (0.10)

0.91 (0.09)

0.494

0.01 (−0.02, 0.05)

0.94 (0.08)

0.067

0.03 (0.00, 0.07)

C

0.88 (0.11)

0.88 (0.10)

-

-

0.87 (0.15)

-

-