| Maternal-fetal | Infant | Father | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | 30 wk gestation | Delivery | Cord blood | 3 mo postpartum | 6 mo postpartum | 3 mo | 6 mo | 12 and 24 mo | |||
Blood/serum/plasma | Calcium | Ra | R | R | R | R | R | R | R | Â | Â |
Phosphate, alkaline phosphatase, creatinine | Â | Â | Â | Â | Â | Â | Â | Sa | Â | Â | |
25(OH)D | R | Â | S | S | Â | S | S | S | Â | Â | |
1,25(OH)2D, whole/bioactive PTH(1–84), C-terminal PTH(73–84), intact PTH, FGF-23 | S |  | S | S |  |  | S | S |  |  | |
PTHrP | S | Â | S | S | S | S | S | S | Â | Â | |
IGF-1, IGFBP-1, IGFBP-3 | Â | Â | Â | S | Â | Â | Â | S | Â | Â | |
Ferritin | Â | Â | Â | Â | Â | Â | Â | S | Â | Â | |
Retinol, folate, cadmium | Â | Â | S | Â | Â | Â | Â | Â | Â | Â | |
C-reactive protein, IL-6, IL-8, TNF-α |  |  | S | S |  |  |  |  |  |  | |
Epigenetic studies | Â | Â | S | S | Â | Â | Â | Â | Â | S | |
Collection for future analyses | R | R | R | R | R | R | R | R | R | R | |
Placenta | Epigenetic studies | Â | Â | R | Â | Â | Â | Â | Â | Â | Â |
Urine | Calcium:creatinine ratio | Â | Â | R | Â | Â | Â | Â | S | Â | Â |
Calcium, phosphate, fluoride, cyclic AMP | Â | Â | Â | Â | Â | Â | Â | S | Â | Â | |
Collection for future analyses | R | Â | R | Â | Â | Â | Â | R | Â | Â | |
Breast milk | PTHrP | Â | Â | Â | Â | S | Â | S | Â | Â | Â |
Collection for future analyses | Â | Â | Â | Â | R | Â | R | Â | Â | Â | |
Nasal swabb | PCR for respiratory viruses | Â | Â | Â | Â | Â | Â | Rb | Rb | Â | Â |
PCR for Streptococcus carriage density | Â | Â | Â | Â | Â | Â | Rb | Rb | Â | Â |