Fig. 1

The effect of various regimens of amphotericin B for experimental cryptococcal meningoencephalitis. Amphotericin B deoxycholate 1 mg/kg was administered daily (b), every third day (c), as an abbreviated regimen for 3 consecutive days (d) and once (e). The solid arrows show the time of drug administration. The data in a-e represent the time course of infection in the cerebrospinal fluid (CSF). Each line represents the fungal burden in an individual rabbit. f shows the fungal density in the cerebrum at the end of the experiment. Each bar represents the mean fungal density ± standard error of the mean. There is no statistically significant difference in the cerebral fungal density of rabbits receiving daily therapy versus those receiving an abbreviated regimen of 1 mg/kg at 48, 72 and 96 h relative to inoculation: *p = 1.00 (not significant), **p = 0.006, ***p = <0.001, ****p = <0.001, *****p = 1.00 (not significant). CFU, colony-forming units. From Livermore J, Howard SJ, Sharp AD, et al. Efficacy of an abbreviated induction regimen of amphotericin B deoxycholate for cryptococcal meningoencephalitis: 3 days of therapy is equivalent to 14 days. MBio 2013; 5 (1): e00725-13. With permission