Flow of patients through the trial. 1. RPFS: Revised Piper Fatigue Scale. 2. ECOG-PS: Eastern Cooperative Oncology Group Performance Status. 3. SRSS: Self-Rating Scale of Sleep. 4. HADS: Hospital Anxiety and Depression Scale. 5. Safety assessment: routine blood test, routine feces test, routine urine test, liver and kidney function tests and electrocardiogram.