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Table 2 Number of deaths, expected number of subjects, and significance level of testing at each preplanned analysis of the primary outcome

From: Comparison of two strategies for initiating renal replacement therapy in the intensive care unit: study protocol for a randomized controlled trial (AKIKI)

  Number of deaths Expected number of subjects Significance level α
Single analysis 263 546 5%
Interim analyses:    
First analysis 90 187 0.15%
Second analysis 180 373 1.81%
Final analysis 270 560* 4.37%
  1. *To take into account a potential loss to follow-up of about 10%, it is planned to include a total of 620 subjects in the study.