Could enteral nutrition improve the outcome of patients with haematological malignancies undergoing allogeneic haematopoietic stem cell transplantation? A study protocol for a randomized controlled trial (the NEPHA study)

Table 2 Schedule of visits and assessment

	Time point
	D-14 to D-7	D1	D7	D14	D21	D28	D60	D90	D180	D270	D360
Informed consent	x
Allocation	x
Energetic and caloric needs assessment			x	x	x	-------------------------------------➔ ¹
Digestive symptoms and tolerance (individual notebook)		x	--------------------------------------------------------- ➔ ²
Functional status (Performance status, sit-up test, dynamometry, Weight, body-mass index, brachial circumference)	x			x		x	x	x	x		x
Hepatic tolerance (Total bilirubin, free and conjugated bilirubin, AST, ALT, ALP, GGT)	x		x	x	x	x	x	x	x	x	x
Transthyretin, C-reactive protein	x		x	x	x	-------------------------------------➔ ³
Albumin	x					x	x	x	x		x
Clinical assessment (GVHD, mucositis, infectious complications, red blood cells and platelets transfusions, catheter complications)			x	x	x	x	x	x	x	x	x
Chimerism						x	x	x	x		x
Quality of life (QLQ-C30)	x							x	x		x

¹Evaluated until hospital discharge; ²Auto-evaluated daily during nutritional intervention; ³Evaluated once per week until hospital discharge; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma-glutamyltransferase.

ISSN: 1745-6215