| Diarrhoea grade | |||
---|---|---|---|---|
Definition/timing | 1 | 2 | 3 | 4 |
Definition | Increase <4 stools/day over baseline; mild increase in ostomy output | Increase 4–6 stools/day over baseline; moderate increase in ostomy output | Increase ≥7 stools/day; incontinence; hospitalization indicated; severe increase in ostomy output limiting self-care | Life-threatening consequences; urgent intervention indicated |
Pre-chemotherapy | Observe but continue to chemotherapy | Stop, stagger or reduce curcumin, continue chemotherapy when AE grade <2 | Stop curcumin, continue with chemotherapy when AE grade <2 | Stop curcumin, continue with chemotherapy when AE grade <2 |
During chemotherapy | Observe but continue chemotherapy | Reduce or stagger curcumin | Stop curcumin, continue or reduce chemotherapy as per protocol | Stop curcumin, continue reduced chemotherapy as per protocol |
48Â hours after one curcumin dose reduction | Observe but continue chemotherapy | Stop curcumin, continue or reduce chemotherapy as per protocol | Stop curcumin, continue or reduce chemotherapy as per protocol | Stop curcumin, continue or reduce chemotherapy as per protocol |