Definition
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Increase <4 stools/day over baseline; mild increase in ostomy output
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Increase 4–6 stools/day over baseline; moderate increase in ostomy output
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Increase ≥7 stools/day; incontinence; hospitalization indicated; severe increase in ostomy output limiting self-care
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Life-threatening consequences; urgent intervention indicated
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Pre-chemotherapy
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Observe but continue to chemotherapy
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Stop, stagger or reduce curcumin, continue chemotherapy when AE grade <2
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Stop curcumin, continue with chemotherapy when AE grade <2
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Stop curcumin, continue with chemotherapy when AE grade <2
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During chemotherapy
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Observe but continue chemotherapy
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Reduce or stagger curcumin
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Stop curcumin, continue or reduce chemotherapy as per protocol
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Stop curcumin, continue reduced chemotherapy as per protocol
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48 hours after one curcumin dose reduction
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Observe but continue chemotherapy
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Stop curcumin, continue or reduce chemotherapy as per protocol
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Stop curcumin, continue or reduce chemotherapy as per protocol
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Stop curcumin, continue or reduce chemotherapy as per protocol
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