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Table 2 Study inclusion and exclusion criteria

From: Immune Function and Muscle Adaptations to Resistance exercise in Older Adults: Study Protocol for a Randomized Controlled Trial of a Nutritional Supplement

Inclusion criteria
• U.S. Military Veteran • Age 60 to 80 years
• Nonsmoker of tobacco products • Body Mass Index of 18.5 - 29.9 kg/m2
Exclusion criteria
• Unstable angina • Uncontrolled diabetes mellitus (HbA1C > 10)
• Allergic to lidocaine • Problems walking or exercising with both legs
• Allergic to vaccination • Metastatic cancer or undergoing chemotherapy
• Allergic to latex or tape • Hernia that causes pain during physical activity
• Seizure in past 3 months • Tetanus or TDAP vaccine in previous two years
• Smokes tobacco products • Certain steroid or androgen use in past 3 months
• Other physician judgment • Cerebral aneurysm or intracranial bleed in past year
• Systemic bacterial infection • Unwilling to halt new use of nutritional supplements
• Active oral or genital herpes • End-stage congestive heart failure (NYHA Stage IV)
• Bleeding or clotting disorders • Unstable abdominal or thoracic aortic aneurysm (>4 cm)
• Encephalopathy in past 7 days • Myocardial infarction or cardiac surgery in past 3 months
• Untreated severe aortic stenosis • Pains, tightness, pressure in chest during physical activity
• Renal disease requiring dialysis • Significantly abnormal blood tests (CBC or PT/PTT/INR)
• Uncontrolled asthma or allergies • Bone fractures in the pelvis, legs, or feet in the last 3 months
• Significant problem with fainting • Taking prescription anti-coagulants (that is, heparin, warfarin, etcetera)
• Current use of appetite stimulants • Current treatment for mania or bipolar disorder or taking lithium
• History of peripheral artery disease • Pulmonary embolism or deep venous thrombosis in past 3 months
• Active suicidality or suicidal ideation • Taking lactulose, nitrates plus hypertension medications or Viagra
• Significant problems with chronic pain • Uncontrolled hypertension or hypotension (>160/100, <100 systolic)
• Unwilling to maintain current normal diet • Acute retinal hemorrhage or ophthalmologic surgery in past 3 months
• Diagnosis of a significant cognitive deficit • Unwilling to halt concurrent use of amino acid or protein supplements
• Guillain-Barre Syndrome in past 3 months • Proliferative diabetic retinopathy or severe nonproliferative retinopathy
• Uncontrolled malignant cardiac arrhythmia • Participated in a weight-lifting program targeting the thighs in last 3 months
• Liver cirrhosis or other severe liver disease • Currently participating in any other research study involving an intervention
• Taking aspirin in any form and unable/unwilling to discontinue for 10 days prior to muscle biopsy
• Taking any non-aspirin non-steroidal anti-inflammatory drug and unable or unwilling to discontinue use for 3 days prior to the muscle biopsy procedure
• Taking Fish Oil, Gingko, Garlic, Saw Palmetto, Turmeric, or Vitamin E and unable or unwilling to discontinue use for 10 days prior to the muscle biopsy procedure