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Table 5 Pharmacokinetic parameter after oral administration of Qishe pill at a dose of 6.33 g•kg-1 to SD rats (mean ± SD, n = 6)

From: Population pharmacokinetic modeling of the Qishe pill in three major traditional Chinese medicine-defined constitutional types of healthy Chinese subjects: study protocol for a randomized controlled trial

Parameters SEA SEI FOR ONO 5-O-M AST-IV
t 1/2 (h) 22.72 ± 11.49 12.35 ± 10.3 51.24 ± 44.19 7.04 ± 3.7 42.79 ± 16.29 11.41 ± 12.51
C max (ng/ml) 53.71 ± 16.14 136.51 ± 45.24 9.39 ± 4.32 2.45 ± 1.51 0.14 ± 0.07 13.3 ± 5.42
T max (h) 0.22 ± 0.07 0.31 ± 0.16 0.22 ± 0.07 0.25 ± 0.00 0.25 ± 0.00 2.00 ± 2.25
AUClast(h*ng/ml) 606.87 ± 161.89 851.3 ± 251.31 38.1 ± 8.04 4.17 ± 1.53 1.13 ± 0.10 107.74 ± 65.65
AUCtot(h*ng/ml) 826.3 ± 229.51 900.76 ± 236.67 71.57 ± 26.49 4.89 ± 1.65 2.31 ± 0.41 129.75 ± 61.01
MRT (h) 36.54 ± 15.27 16.58 ± 6.89 70.4 ± 60.63 9.55 ± 4.04 65.96 ± 20.60 17.9 ± 17.38
CL (L/h/kg) 0.05 ± 0.01 0.02 ± 0.01 0.02 ± 0.00 0.12 ± 0.05 0.16 ± 0.03 0.06 ± 0.07
V z (L/kg) 1.41 ± 0.67 0.41 ± 0.33 0.98 ± 0.43 1.12 ± 0.83 9.38 ± 2.09 0.83 ± 0.94