- Paper Report
- Open Access
Prognostic value of ultrasonographic measurements in stable angina
- Joanna Lyford1
© Biomed Central Ltd 2001
- Received: 15 February 2001
- Published: 18 October 2001
- Coronary disease, plaque, risk factors
Little has been published concerning the prognostic impact of vascular changes in the peripheral arteries. This study aimed to assess the prognostic impact of femoral plaques, carotid plaques, and intima-media thickness.
Carotid intima-media thickness and plaques were related to the risk of CV death or MI. Femoral intima-media thickness was related to CV death and MI, as well as to revascularization, while femoral plaques were only related to the latter. After adjustment for age, sex, smoking, previous CV disease, and lipid status, carotid intima-media thickness failed to predict any CV event, while carotid plaques tended to predict the risk of CV death or MI (P = 0.056). Femoral intima-media thickness and plaques were still related to the risk of revascularization after adjustment (P <0.01 and P<0.05, respectively), although the relationship was weaker. The risk of coronary events increased in proportion to the severity of the plaques, and was more than double in patients with the most severe plaques, compared with healthy counterparts.
A total of 809 patients with stable angina pectoris were studied prospectively during double-blind treatment with verapamil or metoprolol. A subgroup of 558 subjects (182 female, mean age 60?7 years) underwent baseline ultrasonographic assessments of intima-media thickness, lumen diameter, and carotid and femoral artery plaques. After a mean follow-up period of three years, Cox regression analysis was used to identify predictors of CV events (death, nonfatal MI or revascularization).