- Paper Report
- Open Access
Effects of alcohol consumption in patients with left ventricular dysfunction
- T Irvine1
© Biomed Central Ltd 2001
- Received: 20 August 2000
- Published: 17 October 2001
- Alcohol, myocardial infarction, ventricular dysfunction
This paper describes the effect on prognosis of mild to moderate alcohol consumption in patients with left ventricular dysfunction.
This research was undertaken because the effects of moderate alcohol intake on patients with left ventricular dysfunction are unclear. Previous observational studies have shown an association between moderate alcohol intake and reduction in cardiovascular mortality in the general population. The effects of high alcohol intake were not studied in this group.
The authors show that the consumption of up to 14 alcoholic units per week in this study population was associated with an overall 25% reduction in mortality as compared to nondrinkers (7.2 vs 9.4 deaths/100 person years). This effect appeared to be limited to subjects with ischaemic aetiology. In this group, mild to moderate alcohol consumption showed an independent association with decreased risk of all-cause mortality (relative risk 0.85), particularly in death from myocardial infarction (relative risk 0.55). In patients with a nonischaemic aetiology, mild to moderate alcohol consumption had no significant effect on mortality.
Patients studied were a large subgroup (6600 subjects) from the studies of left ventricular dysfunction population. Patients with alcoholic cardiomyopathy were excluded.