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  • Paper Report
  • Open Access

Intracoronary radiation for in-stent restenosis

  • 1
Current Controlled Trials in Cardiovascular Medicine20012:71900

  • Received: 13 September 2000
  • Published:


  • In-stent restenosis, intracoronary radiation


This paper describes the three-year angiographic and clinical outcome following treatment of restenotic coronary arteries with catheter based 192Ir.

This double-blind randomised trial was undertaken to document the long-term efficacy and safety of radiation therapy.

The short-term results of radiation therapy have been promising but its long-term effect has been unknown.

Significant findings

At three-year follow-up target lesion revascularisation was significantly less in the 192Ir group (15.4% vs 48.3%; P <0.01). The dichotomous restenosis rate at 3 years was also significantly less in 192Ir patients (33% vs 64%; P <0.05). No events occurred at either the 6 months or 3 year follow-up to suggest an adverse effect of vascular radiotherapy.


I found this article interesting as it demonstrates a persistence of observed early clinical benefits.

Possible implications of these findings are that vascular radiotherapy may play an important role in the treatment of in-stent restenosis. A limitation of this study is its small sample size. Other studies evaluating the long-term effects of coronary radiation are pending.


A total of 55 patients were enrolled over a 9 month period; 26 were randomised to 192Ir and 29 to placebo.

Additional information

Authors’ Affiliations

University Hospital of Wales, UK


  1. Teirstein PS, Massullo V, Schatz RA, Guarneri EM, Steuterman S, Sirkin K, Cloutier DA, Leon MB, Tripuraneni P: Three-year clinical and angiographic follow-up after intracoronary radiation: results of a randomized clinical trial. Circulation. 2000, 101: 360-365.View ArticlePubMedGoogle Scholar


© Biomed Central Ltd 2001


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