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Table 1 Differences in the cardiovascular risk profiles of oral and transdermal HRT

From: Do we need clinical trials to test the ability of transdermal HRT to prevent coronary heart disease?

Differences that favour

 

transdermal or

 

oral HRT

Parameter

Transdermal

Decrease in factor VII activity, fibrinogen,

 

and triglycerides levels

 

Neutral effect on C-reactive protein

Oral

Decrease in LDL and Lp(a) levels

 

Increase in HDL levels

 

Decrease in PAI-1 levels

  1. Note that coadministration of progestin may influence many of these changes. LDL, low-density lipoprotein.
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Trials

ISSN: 1745-6215