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Table 5 Clinical events committee event rates (%) at 30 days

From: Disagreements between central clinical events committee and site investigator assessments of myocardial infarction endpoints in an international clinical trial: review of the PURSUIT study

  All patients With reclassification*
Event Eptifibatide Placebo P Eptifibatide Placebo P
Death or myocardial infarction       
   Eastern Europe 21.0 19.7   18.0 17.9  
   Latin America 16.1 15.7   14.1 13.2  
   North America 11.7 15.0   11.7 15.0  
   Western Europe 13.8 14.8   12.9 13.7  
   Overall 14.2 15.7 0.042 13.3 14.9 0.021
Myocardial infarction       
   Eastern Europe 18.8 17.3   15.8 15.3  
   Latin America 11.6 11.7   9.6 9.1  
   North America 10.1 12.9   10.1 12.9  
   Western Europe 12.6 12.9   11.7 11.8  
   Overall 12.6 13.6 0.137 11.6 12.7 0.08
  1. *See Methods; 98 patients with low clinical certainty reclassified as having no infarction.