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Archived Comments for: The third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke

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  1. Protocol amendment to be implemented shortly

    Peter Sandercock, University of Edinburgh

    16 October 2009

    This comment is for information only

    Protocol amendments. A number of minor changes to the IST-3 protocol document have been submitted for ethical and regulatory approval. The amended main trial protocol (and a supplementary protocol to describe the planned analyses of the cerebral perfusion data) will be posted on the IST3 website ( when all the appropriate approvals have been obtained, in the near future.

    Trial progress: By 16th October 2009, 1862 patients had been recruited, and the trial is on track to meet the target of 3100 patients by mid 2011.

    For up to date information on recruitment and the implementation of the amendments please see

    Competing interests

    Competing interests:

    Peter Sandercock is the Chief Investigator of IST-3. he has no other relevant competing interests