Outcome measurement in clinical trials for ulcerative colitis: towards standardisation

Table 2 Summary of different properties measured in clinical activity indices

	Author and name of index
	Truelove &Witts [3]	Powell-Tuck [4]	Schroeder [5]	Rachmilewitz [7]	Lichtiger [8]	Seo [9]	Walmsley [10]
Property		St Mark's index	Mayo score, Disease Activity Index (DAI)	Clinical Activity Index (CAI)	Modified Truelove &Witts' Severity Index (MTWSI)	Activity Index	Simple Clinical Colitis Index (SCCAI)
Score range	Mild, Moderate, Severe	0–24	0–12	0–23	0–21	70–300	0–20
Bowel frequency/24 hrs	<4 (mild) >6 (severe)	0–2 (<3 to >6)	0–3 (normal to ≥ 5 above normal)	0–3(<18 to >60/week)	0–4 (≤ 2 to ≥ 10)	add total number/24 hr × 13	0–3(day) 1–2(night)
Stool form		0–2			Need for antidiarrhoeal agents
Urgency					Faecal incontinence 0 or 1		0–3
Blood		0–2	0–3	0–4	0–3	add bloody stools/24 hr × 60	0–3
Abdominal Pain		0–2		0–3	0–3		0–4
Abdominal tenderness		0–4
General well-being		0–3		0–3	0–5		0–4
Anorexia		0–1
Nausea/Vomiting		0–1
Extra-intestinal features		0–3		0–9			0–5
Fever	>37.5°C (severe)	0 – 2 (<37.1 to >38°C)		0 (<38°C) or 3 (>38°C)
Tachycardia	>90
Anaemia	<75% of normal			0 or 4		subtract value × 4
ESR mm/hr	>30			0–2		add value × 0.5
Albumin						subtract value × 15
Sigmoidoscopy		0–2	0–3	0–12
Global assessment			0–3	0–3	0–5	Score = sum of the above and add 200

Note: precise details of the individual components of each score are too complex to be included in a single table: refer to original article or ref [2]

ISSN: 1745-6215