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Table 3 Standard medication to reduce cardiovascular risk in MASTERPLAN

From: Multifactorial approach and superior treatment efficacy in renal patients with the aid of nurse practitioners. Design of The MASTERPLAN Study [ISRCTN73187232]

Medication Recommended dose Point of impact
HMG-CoA Reductase Inhibitor (statin) e.g. atorvastatin 10 mg daily (or comparable dose of other statin) Lipid-metabolism
Acetylsalicylic acid 80 mg daily Thrombocyte aggregation
Folic Acid 5 mg daily Homocysteine metabolism
ACE inhibitor or Angiotensin Receptor Blocker (ARB) e.g. enalapril 5 mg twice daily (or comparable dose of other ACE inhibitor) or irbesartan 75–150 mg (or comparable dose of other ARB) daily Blood pressure, renal function and cardiac pre- and afterload
  1. a In case of proteinuria > 1 g/day: 125/75 mm Hg b NFN: Nederlandse Federatie voor Nefrologie (Dutch Federation for Nephrology) c KDOQI: Kidney Disease Outcomes Quality Initiative d NHG: Nederlands huisartsen genootschap (Dutch College of General Practitioners) e smaller than three times the upper limit of the normal range f GR: Gezondheidsraad (Health Council of the Netherlands) g NNGB: Nederlandse Norm voor Gezond Bewegen (Dutch Standard of Healthful Physical Activity)